AstraZeneca’s vaccine ready for use at the vaccination centre in Apolda, Germany, Sunday, Feb. 28, 2021. THE CANADIAN PRESS/Michael Reichel/dpa via AP

AstraZeneca’s vaccine ready for use at the vaccination centre in Apolda, Germany, Sunday, Feb. 28, 2021. THE CANADIAN PRESS/Michael Reichel/dpa via AP

National panel advises against using Oxford-AstraZeneca’s COVID-19 vaccine on seniors

NACI panel said vaccines from Pfizer and Moderna are preferred for seniors ‘due to suggested superior efficacy’

A national panel of vaccine experts says provinces should not use the Oxford-AstraZeneca COVID-19 vaccine on seniors, opening the door for provinces to start vaccinating younger populations with the newly authorized vaccine much earlier than expected.

But similar advice initially issued in Europe began to be revisited Monday, with France overturning its earlier decision against using it on seniors, and Germany in the midst of reconsidering it.

The Oxford-AstraZeneca vaccine was authorized for use Friday on all adults, including seniors, but the National Advisory Committee on Immunization is concerned there is limited data on how well the vaccine will work in older populations.

There are no concerns that the vaccine is unsafe for use, but the NACI panel said in its recommendations the mRNA vaccines from Pfizer-BioNTech and Moderna are preferred for people 65 years old and above “due to suggested superior efficacy.”

NACI says Oxford-AstraZeneca should be offered to people under 65 as long as the benefits of getting a good vaccine earlier outweigh any limitations the vaccine may have in terms of effectiveness.

Individuals should be made aware of those limitations and how long they might otherwise wait for an mRNA vaccine, the advice says.

The panel’s advice helps provincial governments determine how best to use the vaccines available to them, but provinces can make their own calls about what to do.

It will now be up to provinces to determine if they open up vaccinations with Oxford-AstraZeneca to individuals under the age of 65.

Until now, provinces have not anticipated expanding the vaccination campaign to include people younger than that for several more months, most in what they call Phase 2 or even Phase 3, of their vaccine program.

Alberta Health Minister Tyler Shandro said the provincial government has decided to follow NACI’s advice and not give Oxford-AstraZeneca to anyone over the age of 65.

“How that’s going to change the administration of those who are in Phase 2 is still to be determined,” he said. “We’ll be making those decisions and announcing them fairly soon.”

The NACI advice follows similar plans in many European countries. The European Medicines Agency said the vaccine could be used on all adults, but a number of countries decided not to use it for seniors because of the limited clinical data.

However, France reversed course Monday, with French Health Minister Olivier Véran saying Oxford-AstraZeneca was, along with Pfizer-BioNTech and Moderna, remarkably effective against COVID-19.

A study released last week by Public Health Scotland, where the Oxford-AstraZeneca vaccine has been in use since Dec. 30, found COVID-19-related hospital admissions among seniors fell 94 per cent after getting the vaccine.

Nearly 500,000 people in the study had received the Oxford-AstraZeneca vaccine, most of them over the age of 80.

When vaccines are tested in clinical trials, thousands of participants get the vaccine and a similar number receive a placebo. The vaccine maker then waits until a minimum number of people are infected with COVID-19, and compares how many of those infected got the vaccine and how many did not.

Not enough seniors were among the group who did get infected with COVID-19 to be useful to draw conclusions in the Oxford-AstraZeneca trial. However, data on blood samples showed seniors given the vaccine did develop the antibodies to COVID-19 in similar levels to younger individuals.

Pifzer-BioNTech and Moderna both had more substantial data for older participants in the clinical trials.

Both Pfizer-BioNTech and Moderna reported about 95 per cent effectiveness at preventing COVID-19 overall, while Oxford-AstraZeneca reported its vaccine to be about 62 per cent effective.

Dr. Supriya Sharma, the chief medical adviser at Health Canada overseeing the regulatory review, said Health Canada’s authorization is not out of step with the NACI recommendations.

Sharma said Health Canada noted the concerns about clinical data but authorized the vaccine for use because the data showed the vaccine to be both safe and effective in all adults.

“I agree with the recommendation,” she said Monday in an interview with The Canadian Press.

She said the preference is for those most vulnerable to get the vaccines with the best data available, but for those who are less vulnerable, getting this vaccine now could provide a significant benefit to them and to reducing overall COVID-19 caseloads.

READ MORE: Feds hoping for AstraZeneca shots this week as Pfizer-BioNTech prepare next delivery

Mia Rabson, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

The Nechako Centre building was a retail space built in 1955. The building is now vacant and is listed for sale for $4.4Million. Sitting on 0.72 acres, the building is currently under a redevelopment/revitalization process. (Jacob Lubberts Photo)
Nechako Centre teardown in Kitimat for sale at $4.4 million

B.C. assessments valued the property at $843,000 with a land value of only $492,000

B.C. Finance Minister Selina Robinson outlines the province’s three-year budget in Victoria, April 20, 2021. (B.C. government video)
B.C. deficit to grow by $19 billion for COVID-19 recovery spending

Pandemic-year deficit $5 billion lower than forecast

Raising more than $1,300 for the KVHS’s dementia home project, Dennis and Brenda Horwood leave Kitimat with a bang and start their new retirement journey together. (Photo supplied)
KVHS thanks local Kitimat couple for their contributions to the dementia home project

Dennis and Brenda Horwood raise $1,360 during a retirement garage sale

No increase in fees will be made by the leisure services department in the summer months. Reviews will be made again in May/June for any recommended fee adjustments in the fall. (District of Kitimat photo)
District of Kitimat halt leisure fee increases until the fall

The Leisure Services Advisory Commission recommended no increase take place at this time

Mount Elizabeth Theatre have been approved for a provision of funding by city council for up to $42,000. (Jacob Lubberts photo)
Kitimat’s multi-use theatre grant request approved for live streaming equipment

A funding commitment of up to $42,000 was granted from council to the Mount Elizabeth Theatre

A large crowd protested against COVID-19 measures at Sunset Beach in Vancouver on Tuesday, April 20, 2021. (Snapchat)
VIDEO: Large, police-patrolled crowds gather at Vancouver beach for COVID protests

Vancouver police said they patrolled the area and monitored all gatherings

(Bandstra Transportation photo)
Smithers family-owned business institution sold to publicly-traded company

Bandstra Transportation and Babine Trucking acquired by Mullen Group

FILE – The Instagram app is shown on an iPhone in Toronto on Monday, March 19, 2018. THE CANADIAN PRESS/Graeme Roy
Judge acquits B.C. teen boy ‘set up’ on sex assault charge based on Instagram messages

The girl and her friends did not have ‘good intentions’ towards the accused, judge says

Kai Palkeinen recently helped a car stuck on the riverbed near the Big Eddy Bridge. While the car could not be saved, some of the driver’s belongings were. It’s common for vehicles to get stuck in the area due to significantly changing river levels from Revelstoke Dam. (Photo by Kai Palkeinen)
“I just sank a car’: Revelstoke resident wants Columbia River better protected

Although it’s not permitted, the riverbed near the city is popular for off roading

Meng Wanzhou, chief financial officer of Huawei, walks down the street with an acquaintance after leaving B.C. Supreme Court during a lunch break at her extradition hearing, in Vancouver, B.C., Thursday, April 1, 2021. A judge is scheduled to release her decision today on a request to delay the final leg of hearings in Meng Wanzhou’s extradition case. THE CANADIAN PRESS/Rich Lam
B.C. judge grants Meng Wanzhou’s request to delay extradition hearings

Lawyers for Canada’s attorney general had argued there is no justification to delay proceedings in the case

B.C. Premier John Horgan announces travel restrictions between the province’s regional health authorities at the legislature, April 19, 2021. (B.C. government photo)
B.C. sees 862 more COVID-19 cases Wednesday, seven deaths

Recreational travel restrictions set to begin Friday

B.C. Finance Minister Selina Robinson is photographed following her budget speech in the legislative assembly at the provincial legislature in Victoria, Tuesday, April 20, 2021. THE CANADIAN PRESS/Chad Hipolito
B.C. budget lacks innovative drive, vision during uncertain times, say experts

Finance Minister Selina Robinson’s budget sets out to spend $8.7 billion over three years on infrastructure

Using panels kept cold by water circulating within them, B.C. researchers compared thermal comfort in 60 of the world’s most populous cities, including Toronto. (Lea Ruefenacht)
B.C. researchers use air conditioning to combat spread of COVID particles

Dr. Adam Rysanek and his team have proven a new worthwhile system – a mixture of cooling panels and natural ventilation

Most Read